Maternal and fetal genomes interplay through phosphoinositol 3-kinase(PI3K)-p110α signaling to modify placental resource allocation
نویسندگان
چکیده
منابع مشابه
Maternal-fetal resource allocation: co-operation and conflict.
Pregnancy is generally a co-operative interaction between mother and fetus in which the evolutionary genetic interests of both benefit from production of healthy offspring. While this view is largely supported by empirical data, Kinship Theory predicts that mother and fetus will disagree over the optimum level of maternal investment that maximises their respective fitnesses. This conflict will ...
متن کاملPlacenta plays a critical role in maternal-fetal resource allocation.
Genes and lifestyle were long believed to be the predominant risk factors for the development of major noncommunicable diseases, such as type 2 diabetes and cardiovascular disease. However, a large body of epidemiological evidence has challenged this paradigm by demonstrating that adverse influences during early development, in particular in utero, increase the risk of developing disease in adu...
متن کاملFetal-to-maternal signaling to initiate parturition.
Multiple processes are capable of activating the onset of parturition; however, the specific contributions of the mother and the fetus to this process are not fully understood. In this issue of the JCI, Gao and colleagues present evidence that steroid receptor coactivators 1 and 2 (SRC-1 and SRC-2) regulate surfactant protein-A (SP-A) and platelet-activating factor (PAF) expression, which incre...
متن کاملPlacental mTOR links maternal nutrient availability to fetal growth.
The mTOR (mammalian target of rapamycin) signalling pathway functions as a nutrient sensor, both in individual cells and, more globally, in organs such as the fat body in Drosophila and the hypothalamus in the rat. The activity of placental amino acid transporters is decreased in IUGR (intrauterine growth restriction), and recent experimental evidence suggests that these changes contribute dire...
متن کاملPregnancy Recognition Signaling, Fetal-placental Development and Prenatal Fetal Programming
Contents 1. Introduction 2. Gene expression for uterine proteins and nutrient transporters 2.1. Temporal and spatial changes in steroid hormone receptors in the uterus during the peri-implantation period of pregnancy 3. Pregnancy recognition 3.1. Luteotrophic versus antiluteolytic signaling for pregnancy recognition 3.2. Corpus luteum formation and regression 3.3. Pregnancy recognition signals ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2016
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1602012113